NDLI: Haemopoietic mechanisms in murine allergic upper and lower airway inflammation

Content Provider	PubMed Central
Author	Li, Jing Saito, Hiroko Crawford, Lynn Inman, Mark D. Cyr, Michael M. Denburg, Judah A.
Copyright Year	2005
Abstract	Eosinophil recruitment to the airways, including involvement of haemopoietic eosinophil–basophil progenitors (Eo/B-CFU), is primarily regulated by interleukin-5 (IL-5) and eotaxin. In this study, we investigated the haemopoietic mechanisms in upper and lower airway eosinophilic inflammation. Ovalbumin (OVA) sensitized and challenged BALB/c mice were used to establish isolated upper (UAC), isolated lower (LAC), or combined upper and lower airway (ULAC) inflammation. Airway, blood and bone marrow responses were evaluated in each model. Numbers of airway eosinophils and CD4+ cells were increased significantly in the nasal mucosa in UAC and ULAC mice, and in the lung tissue in LAC and ULAC groups. Levels of IL-5 and eotaxin were increased significantly in the nasal lavage fluid (NL) in UAC and ULAC mice, and in the bronchoalveolar lavage fluid (BAL) in LAC and ULAC groups. The proportion of IL-5-responsive bone marrow Eo/B-CFU was significantly higher than the control in all treatment groups, but peaked much earlier in the ULAC group. Kinetic studies revealed that IL-5 and eotaxin in NL, BAL and serum peaked between 2 and 12 hr after OVA challenge in ULAC mice, and at 24 hr in UAC mice, related to the timing of maximal progenitor responses. These data support the concept that the systemic mechanisms linking rhinitis to asthma depend on the location and extent of airway allergen exposure.
Related Links	http://dx.doi.org/10.1111/j.1365-2567.2005.02109.x
Ending Page	396
Page Count	11
Starting Page	386
File Format	PDF
ISSN	00192805
e-ISSN	13652567
Journal	Immunology
Issue Number	3
Volume Number	114
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2005-03-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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