NDLI: Fetal programming of autonomic and HPA function: do people who were small babies have enhanced stress responses?

Content Provider	PubMed Central
Author	Jones, Alexander Phillips, David I. W.
Copyright Year	2006
Abstract	Studies in several species have demonstrated that an adverse early environment can influence the development of the autonomic nervous system and hypothalamic–pituitary–adrenal (HPA) axis. The autonomic nervous system and HPA axis are key components of the neuroendocrine response to stress and many of these animal models show altered biological responses to stress. Recent research now suggests that these processes operate in humans. An adverse early environment, as evidenced by reduced birth or infant weight, is associated with enhanced autonomic and HPA responses to experimental psychological stress. However, there appear to be marked sex differences in the mechanisms involved. Epidemiological studies demonstrate that physiological changes in these neuroendocrine systems may predispose to cardiovascular disease through their influence on risk factors such as plasma glucose and lipid concentrations and blood pressure. Thus the combination of enhanced stress susceptibility and the psychosocial stressors to which people are exposed may be an important component of the disease risk in human populations.
Related Links	http://dx.doi.org/10.1113/jphysiol.2005.104695
Ending Page	50
Page Count	6
Starting Page	45
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 1
Volume Number	572
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2006-04-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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