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| Content Provider | PubMed Central |
|---|---|
| Author | Lewis, P. Morison, S. Dodge, J. Geddes, D. Coles, E. Russell, G. Littlewood, J. Scott, M. |
| Abstract | BACKGROUND—The UK haspublished observed cohort survival figures for subjects with cysticfibrosis born since 1968. Prior to 1968 cohorts cannot be establisheddirectly from routine data as cystic fibrosis was classified with anumber of unrelated conditions in ICD7. Reported here are interruptedsurvival curves from 1978 for patients with cystic fibrosis born before 1968. METHODS—Life tablesfor the three year cohorts born between 1947 and 1967 were constructedby firstly estimating the numbers of patients with cystic fibrosis bornin each cohort from live birth data and the disease incidence. Thenumber of the estimated cohort that had survived to 1978 is known,which enables the proportion surviving to 1978 to be calculated. Thesurvival of these cohorts after 1978 can be calculated in the usual way. RESULTS—The survivalfor each successive cohort was better than that of the previous one,but most of the improvements appear to have taken place up to the ageof about 20 years. Only 3% of the 1947-49 cohort survived to 30 yearsof age compared with 21% for the 1965-67 cohort, and 3% of the1953-55 cohort survived to 40 years of age. For the later cohorts themortality rate for those aged between 26 and 30 years appears to beabout 50 per 1000 per year. CONCLUSIONS—While thetrend in the numbers surviving into later adulthood is upwards, themortality rates for these ages does not appear to be improving. It isnot possible to tell from these data whether the high mortality ratesin adulthood will improve with better resourced adult clinics or withimproved treatment during childhood. |
| Starting Page | 420 |
| File Format | |
| ISSN | 14683296 |
| e-ISSN | 14683296 |
| Journal | Thorax |
| Issue Number | 5 |
| Volume Number | 54 |
| Language | English |
| Publisher | BMJ Group |
| Publisher Date | 1999-05-01 |
| Access Restriction | Open |
| Rights Holder | BMJ Group |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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