NDLI: Differences between female and male patients with familial rheumatoid arthritis

Content Provider	PubMed Central
Author	Laivoranta-nyman, S. Luukkainen, R. Hakala, M. Hannonen, P. Mottonen, T. Yli-kerttula, U. Ilonen, J. Toivanen, A.
Abstract	OBJECTIVE—To determine whether there are genetic differences between female and male patients with familial rheumatoid arthritis (RA). METHODS—45 men and 119 women from 78 families with RA who all had at least one first degree relative with RA were compared. HLA-DRB1 alleles were analysed, including DRB104 subtypes and associations of DRB104 haplotypes with DQB10301 or DQB10302 alleles, the age of the patients at disease onset, the presence of rheumatoid factor (RF), joint erosions, and rheumatoid nodules. RESULTS—HLA-DRB1*13 allele (the subtype allele of DR6, reported to be protective against the development of RA) was found in 14/119 (12%) of female but in none of the male patients (p=0.036). The HLA-DR4 allele was found slightly more often in men than women patients with familial RA (31/45 (69%) v 75/119 (63%), NS). Men were also more often RF positive than women (44/45 (98%) v 98/117 (84%); p=0.031). On the other hand, the mean age at onset of RA was significantly lower in the female group (40.4 years) than in men (46.6 years, p=0.0044). CONCLUSION—The results indicate that there is stronger genetic background in familial male than female patients with RA in the genetic susceptibility defined by the studied HLA antigens. However, the earlier age of onset of the disease in female group and the increased proportion of women with RA indicate that there are additional sex related predisposing factors enhanced in familial cases.
Related Links	http://dx.doi.org/10.1136/ard.60.4.413
Ending Page	415
Page Count	3
Starting Page	413
File Format	PDF
ISSN	00034967
e-ISSN	14682060
Journal	Annals of the Rheumatic Diseases
Issue Number	4
Volume Number	60
Language	English
Publisher Date	2001-04-01
Access Restriction	Open
Subject Keyword	Immunology Biochemistry, Genetics and Molecular Biology(all) Immunology and Allergy Rheumatology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Biochemistry, Genetics and Molecular Biology Immunology Rheumatology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Immunogenetic differencies between patients with familial and non-familial rheumatoid arthritis

Association between bronchiectasis and smoking in patients with rheumatoid arthritis

Release of cartilage and bone macromolecules into synovial fluid: differences between psoriatic arthritis and rheumatoid arthritis

Epistatic interaction between FCRL3 and NFκB1 genes in Spanish patients with rheumatoid arthritis

Dynamic exercises in patients with rheumatoid arthritis

Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study

Abnormal IgA levels in patients with rheumatoid arthritis

Labour force participation among patients with rheumatoid arthritis

Assessing periarticular bone mineral density in patients with early psoriatic arthritis or rheumatoid arthritis

Differences between female and male patients with familial rheumatoid arthritis

Similar Documents

Immunogenetic differencies between patients with familial and non-familial rheumatoid arthritis

Association between bronchiectasis and smoking in patients with rheumatoid arthritis

Release of cartilage and bone macromolecules into synovial fluid: differences between psoriatic arthritis and rheumatoid arthritis

Epistatic interaction between FCRL3 and NFκB1 genes in Spanish patients with rheumatoid arthritis

Dynamic exercises in patients with rheumatoid arthritis

Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study

Abnormal IgA levels in patients with rheumatoid arthritis

Labour force participation among patients with rheumatoid arthritis

Assessing periarticular bone mineral density in patients with early psoriatic arthritis or rheumatoid arthritis

Differences between female and male patients with familial rheumatoid arthritis