NDLI: Concurrence of sarcoidosis and aortitis: case report and review of the literature

Content Provider	PubMed Central
Author	Redtenbacher, S. Bancher, C. Fischer, M. Smolen, J. Weiler, V.
Abstract	Takayasu arteritis (TA) is a rare manifestation of systemic large vessel vasculitis which affects predominantly the aorta and its main branches, but often remains unrecognised owing to delayed diagnosis and non-characteristic clinical features. Sarcoidosis, too, is a systemic inflammatory disease which can affect virtually any organ system. Reports about the coincidence of both diseases have appeared.  The case presented here is characterised by a significant time lag between detection of TA and appearance of clinical signs of sarcoidosis. The woman, now 39 years old, had erythema nodosum, circumscript alopecia, and recurrent uveitis, which dated back to 1980 and was attributed to sarcoidosis. At least 12 years later aortic valve insufficiency with progressive cardiac failure developed. Histology performed at the time of aortic valve prosthesis in 1997 disclosed a diagnosis of TA, which was confined to the aortic root. Incidentally, sarcoidosis was diagnosed in adjacent lymph nodes. A thorough check up failed to detect further manifestations of TA; thus, possibly, the patients had aortitis similar to, but not identical with, TA. Several related cases previously reported are discussed, suggesting that both diseases may be inherently related as they are characterised by certain non-specific, immunoinflammatory abnormalities. This case report suggests that the prevalence of TA, or related forms of arteritis, may be higher than expected and should be considered, especially in younger patients with non-characteristic cardiovascular symptoms and suspected systemic inflammatory disease. Moreover, the association with sarcoidosis in this and other previously described cases suggests that the two diseases may be related and that TA or TA-like vasculitis may even be a complication of sarcoidosis.
Related Links	http://dx.doi.org/10.1136/ard.59.11.850
Ending Page	853
Page Count	4
Starting Page	850
File Format	PDF
ISSN	00034967
e-ISSN	14682060
Journal	Annals of the Rheumatic Diseases
Issue Number	11
Volume Number	59
Language	English
Publisher Date	2000-11-01
Access Restriction	Open
Subject Keyword	Immunology Biochemistry, Genetics and Molecular Biology(all) Immunology and Allergy Rheumatology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Biochemistry, Genetics and Molecular Biology Immunology Rheumatology

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