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| Content Provider | PubMed Central |
|---|---|
| Author | Nightingale, J. Rogers, D. Hart, L. Kharitonov, S. Chung, K. Barnes, P. |
| Abstract | BACKGROUND—Inhalationof lipopolysaccharide (LPS) causes an inflammatory response in thelungs. To explore this response, inflammatory indices were measured ininduced sputum from atopic asthmatic patients and compared with atopicand non-atopic subjects after inhalation of LPS. METHODS—Theeffects of inhaled LPS (60 µg) or placebo (0.9% saline) wereexamined in a randomised, double blind, crossover trial in 11 non-atopic normal subjects, seven atopic, non-asthmaticindividuals, and eight atopic, asthmatic patients. Sputum wasinduced by inhalation of 3.5% saline before the test inhalationand again at six hours and 24 hours. Spirometry (forced expiratoryvolume in one second (FEV1), forced vital capacity(FVC)), heart rate, blood pressure, and temperature were recordedbefore challenge and at intervals until eight hours, and at 24 hoursafter challenge. RESULTS—Therewas no change in cardiovascular parameters or spirometry with eitherexposure in any group. In the asthmatic patients only, inhalationof LPS caused a rise in temperature, with a peak of 0.6°C at sevenhours, which was significantly higher than following placeboinhalation (p<0.05). In normal subjects, LPS caused a significant risein absolute neutrophil counts at 24 hours compared with placebo (median1.1 × 106 cells/ml after LPS; median 0.2 × 106 cells/ml after placebo, p<0.01), but no change indifferential counts. In asthmatic patients, LPS caused a significantrise in differential neutrophil counts at six hours compared withplacebo (median 88% after LPS; median 56% after placebo, p<0.05),but no change in absolute cell counts at any time point. There was nochange in neutrophil counts in the atopic subjects. There was asignificant rise in sputum interleukin 8 (IL-8) concentrations innormal subjects at six hours compared with placebo (mean placebo 1.1 ng/ml; LPS 3.0 ng/ml, p<0.05) and in asthmatics at 24 hours (meanplacebo 2.0 ng/ml, LPS 6.9 ng/ml, p<0.05). There were no changes insputum concentrations of tumour necrosis factor α or granulocytemacrophage colony stimulating factor at any time. CONCLUSIONS—Inhalationof LPS causes a neutrophilic inflammation with increases in IL-8 inboth normal and asthmatic subjects. |
| Starting Page | 563 |
| File Format | |
| ISSN | 14683296 |
| e-ISSN | 14683296 |
| Journal | Thorax |
| Issue Number | 7 |
| Volume Number | 53 |
| Language | English |
| Publisher | BMJ Group |
| Publisher Date | 1998-07-01 |
| Access Restriction | Open |
| Rights Holder | BMJ Group |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
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