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| Content Provider | PubMed Central |
|---|---|
| Author | Verschuuren, J. Perquin, M. De Baets, M. Vriesman, P. V. Twijnstra, A. Ten, V. |
| Abstract | OBJECTIVES—To followup the level of anti-Hu antibody titres during chemotherapy and tocompare the pattern of metastases and other neurological complicationsbefore and after chemotherapy in patients with small cell lung cancer(SCLC) with and without low titre anti-Hu antibodies. Seventeen percent of patients with SCLC without paraneoplastic syndromes have a lowtitre of anti-Hu antibodies in their serum. Previous studies suggestedthat these antibodies correlate with a more indolent tumour growth. METHODS—The serum of52 consecutive patients with SCLC were studied before and duringchemotherapy, and the correlation with stage of disease and pattern ofmetastases was examined. All serum samples were investigated usingwestern blot and enzyme linked immunosorbent assay (ELISA) with HuD recombinant protein. All patients with SCLC wereinvestigated using MRI of the brain, CSF, bone marrow aspiration,ultrasound of the abdomen, and radionuclide bone scan. RESULTS—Nine (17%) of52 SCLC serum samples were positive by western blot. At the time ofdiagnosis none of the anti-Hu positive patients had either CNS (brainor leptomeningeal), epidural, adrenal, or bone marrow metastases and56% had limited disease. In eight of 43 anti-Hu negative patients CNSmetastases were found at the time of diagnosis, and only 30% hadlimited disease. The prevalence of bone and liver metastases wassimilar in both groups. Survival was 11 (SD ) months for the 43 anti-Hunegative and 10 (SD 6) months for the nine anti-Hu positive patients.Male:female ratio in the anti-Hu negative group was 4.4:1, and in theanti-Hu positive group 2:1. CONCLUSIONS—No anti-Huantibody positive serum, as tested by western blot, became negativeduring chemotherapy. Anti-Hu positive and anti-Hu negative patients hadsimilar survival, but anti-Hu positive patients tended to be women, hadlimited disease at the time of tumour diagnosis, and initiallymetastases seemed to spare the nervous system. |
| Starting Page | 353 |
| File Format | |
| ISSN | 1468330X |
| e-ISSN | 1468330X |
| Journal | Journal of Neurology, Neurosurgery, and Psychiatry |
| Issue Number | 3 |
| Volume Number | 67 |
| Language | English |
| Publisher | BMJ Group |
| Publisher Date | 1999-09-01 |
| Access Restriction | Open |
| Rights Holder | BMJ Group |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery Psychiatry and Mental Health |
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