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| Content Provider | PubMed Central |
|---|---|
| Author | Poovorawan, Y. Sanpavat, S. Chumdermpadetsuk, S. Safary, A. |
| Abstract | Neonates of hepatitis B surface antigen (HBsAg) positive and hepatitis B encoded antigen (HBeAg) positive mothers received 10 µg of recombinant hepatitis B vaccine at months 0, 1, 6, or 0, 1, 2, 12, with or without immunoglobulin at birth, and were followed up to the age of 8 years for HBsAg, anti-HBc, and anti-HBs. Some were boosted at month 60. The overall vaccine protection at month 12 was 96.2%. No child became a chronic carrier beyond the age of 3 years, showing that this vaccine provides immediate protection against HBsAg carriage, and long term protection against fetally acquired HBsAg. After month 60 hepatitis B serological markers without disease, indicating re-exposure to HBV, reappeared in comparable numbers among boosted and non-boosted children (5 for a total of 167 children). This vaccine provides long term protection against hepatitis B chronic carriage and infection in high risk neonates with or without a month 60 booster. A booster at the age of 5-6 years or 11-12 years would reduce HBV infection, viral circulation and transmission, while ensuring long term antibody persistence. Keywords: hepatitis B vaccine; transmission; boosters; long term efficacy |
| Starting Page | 47 |
| File Format | |
| ISSN | 14682052 |
| e-ISSN | 14682052 |
| Journal | Archives of Disease in Childhood Fetal and Neonatal Edition |
| Issue Number | 1 |
| Volume Number | 77 |
| Language | English |
| Publisher Date | 1997-07-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health Obstetrics and Gynecology |
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