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| Content Provider | PubMed Central |
|---|---|
| Author | Zhu, Bin Zhao, Ming-wei Gilbert, Eriani Wang, En-duo |
| Copyright Year | 2007 |
| Abstract | Leucyl-, isoleucyl-, and valyl-tRNA synthetases form a subgroup of related aminoacyl-tRNA synthetases that attach similar amino acids to their cognate tRNAs. To prevent amino acid misincorporation during translation, these enzymes also hydrolyze mischarged tRNAs through a post-transfer editing mechanism. Here we show that LeuRS from the deep-branching bacterium Aquifex aeolicus edits the complete set of aminoacylated tRNAs generated by the three enzymes: Ile-tRNAIle, Val-tRNAIle, Val-tRNAVal, Thr-tRNAVal, and Ile-tRNALeu. This unusual enlarged editing property was studied in a model of a primitive editing system containing a composite minihelix carrying the triple leucine, isoleucine, and valine identity mimicking the primitive tRNA precursor. We found that the freestanding LeuRS editing domain can edit this precursor in contrast to IleRS and ValRS editing domains. These results suggest that A. aeolicus LeuRS carries editing properties that seem more primitive than those of IleRS and ValRS. They suggest that the A. aeolicus editing domain has preserved the ambiguous editing property from the ancestral common editing domain or, alternatively, that this plasticity results from a specific metabolic adaptation. |
| Related Links | http://dx.doi.org/10.1261/rna.228707 |
| Ending Page | 21 |
| Page Count | 7 |
| Starting Page | 15 |
| File Format | |
| ISSN | 13558382 |
| e-ISSN | 14699001 |
| Journal | RNA |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2006-11-01 |
| Access Restriction | Open |
| Rights Holder | Cold Spring Harbor Laboratory Press |
| Subject Keyword | Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology |
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