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| Content Provider | PubMed Central |
|---|---|
| Author | Guy, Mareels Poyck, Paul P. C. Sunny, Eloot Chamuleau, Robert A. F. M. Verdonck, Pascal R. |
| Abstract | A numerical model to investigate fluid flow and oxygen (O2) transport and consumption in the AMC-Bioartificial Liver (AMC-BAL) was developed and applied to two representative micro models of the AMC-BAL with two different gas capillary patterns, each combined with two proposed hepatocyte distributions. Parameter studies were performed on each configuration to gain insight in fluid flow, shear stress distribution and oxygen availability in the AMC-BAL. We assessed the function of the internal oxygenator, the effect of changes in hepatocyte oxygen consumption parameters in time and the effect of the change from an experimental to a clinical setting. In addition, different methodologies were studied to improve cellular oxygen availability, i.e. external oxygenation of culture medium, culture medium flow rate, culture gas oxygen content (pO2) and the number of oxygenation capillaries. Standard operating conditions did not adequately provide all hepatocytes in the AMC-BAL with sufficient oxygen to maintain O2 consumption at minimally 90% of maximal uptake rate. Cellular oxygen availability was optimized by increasing the number of gas capillaries and pO2 of the oxygenation gas by a factor two. Pressure drop over the AMC-BAL and maximal shear stresses were low and not considered to be harmful. This information can be used to increase cellular efficiency and may ultimately lead to a more productive AMC-BAL. |
| Related Links | http://dx.doi.org/10.1007/s10439-006-9169-6 |
| Ending Page | 1744 |
| Page Count | 16 |
| Starting Page | 1729 |
| File Format | |
| ISSN | 00906964 |
| e-ISSN | 15216047 |
| Journal | Annals of Biomedical Engineering |
| Issue Number | 11 |
| Volume Number | 34 |
| Language | English |
| Publisher | Kluwer Academic Publishers-Plenum Publishers |
| Publisher Date | 2006-11-02 |
| Access Restriction | Open |
| Rights Holder | Kluwer Academic Publishers-Plenum Publishers |
| Subject Keyword | Biomedical Engineering Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomedical Engineering |
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