NDLI: Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice

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Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice

Content Provider	PubMed Central
Author	Reed, Danielle R. Mcdaniel, Amanda H. Li, Xia Tordoff, Michael G. Bachmanov, Alexander A.
Abstract	To understand how genotype influences fat patterning and obesity, we conducted an autosomal genome scan using male and female F2 hybrids between the C57BL/6ByJ and 129P3/J parental mouse strains. Mice were studied in middle-adulthood and were fed a low-energy, low-fat diet during their lifetime. We measured the weight of the retroperitoneal adipose depot (near the kidney) and the gonadal adipose depot (near the epididymis in males and ovaries in females). An important feature of the analysis was the comparison of linkage results for absolute adipose depot weight and depot weight adjusted for body size, i.e., relative weight. We detected 67 suggestive linkages for six phenotypes, which fell into one of three categories: those specific to absolute but not relative depot weight (Chr 5, 11, and 14), those specific to relative but not absolute depot weight (Chr 9, 15, and 16), and those involving both (Chr 2 and 7). Some quantitative trait loci (QTLs) affected one adipose depot more than another: Retroperitoneal depot weight was linked to Chr 8, 11, 12, and 17, but the linkage effects for the gonadal depot were stronger for Chr 5, 7, and 9. Several linkages were specific to sex; for instance, the absolute weight of gonadal fat was linked to Chromosome 7 in male (LOD = 3.4) but not female mice (LOD = 0.2). Refining obesity as a phenotype may uncover clues about gene function that will assist in positional cloning efforts.
Related Links	http://dx.doi.org/10.1007/s00335-006-0054-2
Starting Page	1065
File Format	PDF
ISSN	14321777
e-ISSN	14321777
Journal	Mammalian genome : official journal of the International Mammalian Genome Society
Issue Number	11
Volume Number	17
Language	English
Publisher Date	2006-11-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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