NDLI: Schistosoma japonicum Reinfection after Praziquantel Treatment Causes Anemia Associated with Inflammation▿

Content Provider	PubMed Central
Author	Leenstra, Tjalling Coutinho, Hannah M. Acosta, Luz P. Langdon, Gretchen C. Su, Li Olveda, Remigio M. Mcgarvey, Stephen T. Kurtis, Jonathan D. Friedman, Jennifer F.
Copyright Year	2006
Abstract	There is a relationship between schistosomiasis and anemia, although the magnitude and exact mechanisms involved are unclear. In a cohort of 580 Schistosoma japonicum-infected 7- to 30-year-old patients from Leyte, The Philippines, we evaluated the impact of reinfection with S. japonicum after treatment with praziquantel on the mean hemoglobin level, iron-deficiency (IDA) and non-iron-deficiency anemia (NIDA), and inflammatory markers. All participants were treated at baseline and followed up every 3 months for a total of 18 months. At each follow-up, participants provided stools to quantify reinfection and venous blood samples for hemograms and measures of iron status and inflammation. After 18 months, reinfection with S. japonicum was associated with a lower mean hemoglobin level (−0.39 g/dl; 95% confidence interval [95% CI], −0.63 to −0.16) and 1.70 (95% CI, 1.10 to 2.61) times higher odds of all-cause anemia than those without reinfection. Reinfection was associated with IDA for high reinfection intensities only. Conversely, reinfection was associated with NIDA for all infection intensities. Reinfection was associated with serum interleukin-6 responses (P < 0.01), and these responses were associated with NIDA (P = 0.019) but not with IDA (P = 0.29). Our results provide strong evidence for the causal relationship between S. japonicum infection and anemia. Rapidly reinfected individuals did not have the positive treatment effect on hemoglobin seen in nonreinfected individuals. The principle mechanism involved in S. japonicum-associated anemia is that of proinflammatory cytokine-mediated anemia, with iron deficiency playing a role in high-intensity infections. Based on the proposed mechanism, anemia is unlikely to be ameliorated by iron therapy alone.
Related Links	http://dx.doi.org/10.1128/iai.00757-06
Ending Page	6407
Page Count	10
Starting Page	6398
File Format	PDF
ISSN	00199567
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	11
Volume Number	74
Language	English
Publisher	American Society for Microbiology
Publisher Date	2006-11-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment

T-Helper-2 Cytokine Responses to Sj97 Predict Resistance to Reinfection with Schistosoma japonicum

Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment

Immunoglobulin E (IgE) Responses to Paramyosin Predict Resistance to Reinfection with Schistosoma japonicum and Are Attenuated by IgG4▿

Transdermal praziquantel administration attenuates hepatic granulomatosis in mice infected with Schistosoma japonicum

Artemether Treatment of Prepatent Schistosoma japonicum Induces Resistance to Reinfection in Association with Reduced Pathology

Human immunoglobulin E responses to a recombinant 22.6-kilodalton antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment.

Human T- and B-Cell Responses to Schistosoma mansoni Recombinant Glyceraldehyde 3-Phosphate Dehydrogenase Correlate with Resistance to Reinfection with S. mansoni or Schistosoma haematobium after Chemotherapy

Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice

Schistosoma japonicum Reinfection after Praziquantel Treatment Causes Anemia Associated with Inflammation▿

Similar Documents

Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment

T-Helper-2 Cytokine Responses to Sj97 Predict Resistance to Reinfection with Schistosoma japonicum

Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment

Immunoglobulin E (IgE) Responses to Paramyosin Predict Resistance to Reinfection with Schistosoma japonicum and Are Attenuated by IgG4▿

Transdermal praziquantel administration attenuates hepatic granulomatosis in mice infected with Schistosoma japonicum

Artemether Treatment of Prepatent Schistosoma japonicum Induces Resistance to Reinfection in Association with Reduced Pathology

Human immunoglobulin E responses to a recombinant 22.6-kilodalton antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment.

Human T- and B-Cell Responses to Schistosoma mansoni Recombinant Glyceraldehyde 3-Phosphate Dehydrogenase Correlate with Resistance to Reinfection with S. mansoni or Schistosoma haematobium after Chemotherapy

Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice

Schistosoma japonicum Reinfection after Praziquantel Treatment Causes Anemia Associated with Inflammation▿