NDLI: Direct and indirect immunosuppression by a malaria parasite in its mosquito vector.

Content Provider	PubMed Central
Author	Christophe, Boëte Paul, Richard E. L. Koella, Jacob C.
Abstract	Malaria parasites develop as oocysts within the haemocoel of their mosquito vector during a period that is longer than the average lifespan of many of their vectors. How can they escape from the mosquito's immune responses during their long development? Whereas older oocysts might camouflage themselves by incorporating mosquito-derived proteins into their surface capsule, younger stages are susceptible to the mosquito's immune response and must rely on other methods of immune evasion. We show that the malaria parasite Plasmodium gallinaceum suppresses the encapsulation immune response of its mosquito vector, Aedes aegypti, and in particular that the parasite uses both an indirect and a direct strategy for immunosuppression. Thus, when we fed mosquitoes with the plasma of infected chickens, the efficacy of the mosquitoes to encapsulate negatively charged Sephadex beads was considerably reduced, whether the parasite was present in the blood meal or not. In addition, zygotes that were created ex vivo and added to the blood of uninfected chickens reduced the efficacy of the encapsulation response. As dead zygotes had no effect on encapsulation, this result demonstrates active suppression of the mosquito's immune response by malaria parasites.
Related Links	http://dx.doi.org/10.1098/rspb.2004.2762
Ending Page	1615
Page Count	5
Starting Page	1611
File Format	PDF
ISSN	09628452
e-ISSN	14712954
Journal	Proceedings of the Royal Society B: Biological Sciences
Issue Number	1548
Volume Number	271
Language	English
Publisher Date	2004-08-07
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Agricultural and Biological Sciences(all) Environmental Science(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology Environmental Science Agricultural and Biological Sciences

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The malaria parasite, Plasmodium falciparum, increases the frequency of multiple feeding of its mosquito vector, Anopheles gambiae.

Interspecific competition during transmission of two sympatric malaria parasite species to the mosquito vector.

Insecticide exposure impacts vector–parasite interactions in insecticide-resistant malaria vectors

Density-dependent impact of the human malaria parasite Plasmodium falciparum gametocyte sex ratio on mosquito infection rates

Direct manipulation of insect reproduction by agents of parasite origin

Evolution of direct and indirect reciprocity

Genetic and environmental determinants of malaria parasite virulence in mosquitoes.

Close kinship within multiple-genotype malaria parasite infections

Inferring malaria parasite population structure from serological networks

Direct and indirect immunosuppression by a malaria parasite in its mosquito vector.

Similar Documents

The malaria parasite, Plasmodium falciparum, increases the frequency of multiple feeding of its mosquito vector, Anopheles gambiae.

Interspecific competition during transmission of two sympatric malaria parasite species to the mosquito vector.

Insecticide exposure impacts vector–parasite interactions in insecticide-resistant malaria vectors

Density-dependent impact of the human malaria parasite Plasmodium falciparum gametocyte sex ratio on mosquito infection rates

Direct manipulation of insect reproduction by agents of parasite origin

Evolution of direct and indirect reciprocity

Genetic and environmental determinants of malaria parasite virulence in mosquitoes.

Close kinship within multiple-genotype malaria parasite infections

Inferring malaria parasite population structure from serological networks

Direct and indirect immunosuppression by a malaria parasite in its mosquito vector.