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| Content Provider | PubMed Central |
|---|---|
| Author | Kopp, Hans-georg Hooper, Andrea T. Broekman, M. Johan Avecilla, Scott T. Petit, Isabelle Luo, Min Milde, Till Ramos, Carlos A. Zhang, Fan Kopp, Tabitha Bornstein, Paul Jin, David K. Marcus, Aaron J. Rafii, Shahin |
| Copyright Year | 2006 |
| Abstract | Thrombopoietic cells may differentially promote or inhibit tissue vascularization by releasing both pro- and antiangiogenic factors. However, the molecular determinants controlling the angiogenic phenotype of thrombopoietic cells remain unknown. Here, we show that expression and release of thrombospondins (TSPs) by megakaryocytes and platelets function as a major antiangiogenic switch. TSPs inhibited thrombopoiesis, diminished bone marrow microvascular reconstruction following myelosuppression, and limited the extent of revascularization in a model of hind limb ischemia. We demonstrate that thrombopoietic recovery following myelosuppression was significantly enhanced in mice deficient in both TSP1 and TSP2 (TSP-DKO mice) in comparison with WT mice. Megakaryocyte and platelet levels in TSP-DKO mice were rapidly restored, thereby accelerating revascularization of myelosuppressed bone marrow and ischemic hind limbs. In addition, thrombopoietic cells derived from TSP-DKO mice were more effective in supporting neoangiogenesis in Matrigel plugs. The proangiogenic activity of TSP-DKO thrombopoietic cells was mediated through activation of MMP-9 and enhanced release of stromal cell–derived factor 1. Thus, TSP-deficient thrombopoietic cells function as proangiogenic agents, accelerating hemangiogenesis within the marrow and revascularization of ischemic hind limbs. As such, interference with the release of cellular stores of TSPs may be clinically effective in augmenting neoangiogenesis. |
| Related Links | http://dx.doi.org/10.1172/jci29314 |
| Ending Page | 3291 |
| Page Count | 15 |
| Starting Page | 3277 |
| File Format | |
| ISSN | 00219738 |
| Journal | Journal of Clinical Investigation |
| Issue Number | 12 |
| Volume Number | 116 |
| Language | English |
| Publisher | American Society for Clinical Investigation |
| Publisher Date | 2006-12-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Clinical Investigation |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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