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| Content Provider | PubMed Central |
|---|---|
| Author | Günther, Stefan Hempel, Dorothea Dunkel, Mathias Rother, Kristian Preissner, Robert |
| Copyright Year | 2006 |
| Abstract | The immune system protects organisms from foreign proteins, peptide epitopes and a multitude of chemical compounds. Among these, haptens are small molecules, eliciting an immune response when conjugated with carrier molecules. Known haptens are xenobiotics or natural compounds, which can induce a number of autoimmune diseases like contact dermatitis or asthma. Furthermore, haptens are utilized in the development of biosensors, immunomodulators and new vaccines. Although hapten-induced allergies account for 6–10% of all adverse drug effects, the understanding of the correlation between structural and haptenic properties is rather fragmentary. We have developed a manually curated hapten database, SuperHapten, integrating information from literature and web resources. The current version of the database compiles 2D/3D structures, physicochemical properties and references for about 7500 haptens and 25,000 synonyms. The commercial availability is documented for about 6300 haptens and 450 related antibodies, enabling experimental approaches on cross-reactivity. The haptens are classified regarding their origin: pesticides, herbicides, insecticides, drugs, natural compounds, etc. Queries allow identification of haptens and associated antibodies according to functional class, carrier protein, chemical scaffold, composition or structural similarity. SuperHapten is available online at . |
| Related Links | http://dx.doi.org/10.1093/nar/gkl849 |
| Starting Page | 906 |
| File Format | |
| ISSN | 03051048 |
| e-ISSN | 13624962 |
| Journal | Nucleic Acids Research |
| Issue Number | Database issue |
| Volume Number | 35 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2007-01-03 |
| Access Restriction | Open |
| Rights Holder | Oxford University Press |
| Subject Keyword | Genetics Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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