NDLI: Effect of high intensity training on capillarization and presence of angiogenic factors in human skeletal muscle

Content Provider	PubMed Central
Author	Jensen, L. Bangsbo, J. Hellsten, Y.
Copyright Year	2004
Abstract	The effect of intense training on endothelial proliferation, capillary growth and distribution of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) was examined in human skeletal muscle. Two intermittent knee extensor training protocols (at ∼150% (Study 1) versus ∼90% (Study 2) of leg V˙ O2 max) were conducted. Muscle biopsies were obtained throughout the training periods for immunohistochemical assessment of capillarization, cell proliferation (Ki-67-positive cells), VEGF and bFGF. In Study 1, microdialysis samples were collected from the trained and untrained leg at rest and during exercise and added to endothelial cells to measure the proliferative effect. After 4 weeks of training there was a higher (P < 0.05) capillary-to-fibre ratio (Study 1: 2.4 ± 0.1 versus 1.7 ± 0.1) and number of Ki-67-positive cells (Study 1: 0.18 ± 0.05 versus 0.00 ± 0.01) than before training. Neither the location of proliferating endothelial cells nor capillarization was related to muscle fibre type. The endothelial cell proliferative effect of the muscle microdialysate increased from rest to exercise in both the untrained leg (from 262 ± 60 to 573 ± 87% of control perfusate) and the trained leg (from 303 ± 75 to 415 ± 108% of perfusate). VEGF and bFGF were localized in endothelial and skeletal muscle cells and training induced no changes in distribution. The results demonstrate that intense intermittent endurance training induces capillary growth and a transient proliferation of endothelial cells within 4 weeks, with a similar growth occurring around type I versus type II muscle fibres.
Related Links	http://dx.doi.org/10.1113/jphysiol.2003.057711
Ending Page	582
Page Count	12
Starting Page	571
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 2
Volume Number	557
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2004-06-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle

Effects of high-intensity intermittent training on potassium kinetics and performance in human skeletal muscle

Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training

AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise

Training for skeletal muscle capillarization: a Janus-faced role of exercise intensity?

A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms

Different skeletal muscle HSP70 responses to high-intensity strength training and low-intensity endurance training

Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise

No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men

Effect of high intensity training on capillarization and presence of angiogenic factors in human skeletal muscle

Similar Documents

The effect of passive movement training on angiogenic factors and capillary growth in human skeletal muscle

Effects of high-intensity intermittent training on potassium kinetics and performance in human skeletal muscle

Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training

AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise

Training for skeletal muscle capillarization: a Janus-faced role of exercise intensity?

A practical model of low-volume high-intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms

Different skeletal muscle HSP70 responses to high-intensity strength training and low-intensity endurance training

Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise

No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men

Effect of high intensity training on capillarization and presence of angiogenic factors in human skeletal muscle