NDLI: Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

Content Provider	PubMed Central
Author	Trebino, Catherine E. Stock, Jeffrey L. Gibbons, Colleen P. Naiman, Brian M. Wachtmann, Timothy S. Umland, John P. Pandher, Karamjeet Lapointe, Jean-martin Saha, Sipra Roach, Marsha L. Carter, Demetrius Thomas, Nathalie A. Durtschi, Becky A. Mcneish, John D. Hambor, John E. Jakobsson, Per-johan Carty, Thomas J. Perez, Jose R. Audoly, Laurent P.
Copyright Year	2003
Abstract	Prostaglandin (PG)E2 is a potent mediator of pain and inflammation, and high levels of this lipid mediator are observed in numerous disease states. The inhibition of PGE2 production to control pain and to treat diseases such as rheumatoid arthritis to date has depended on nonsteroidal antiinflammatory agents such as aspirin. However, these agents inhibit the synthesis of all prostanoids. To produce biologically active PGE2, PGE synthases catalyze the isomerization of PGH2 into PGE2. Recently, several PGE synthases have been identified and cloned, but their role in inflammation is not clear. To study the physiological role of the individual PGE synthases, we have generated by targeted homologous recombination a mouse line deficient in microsomal PGE synthase 1 (mPGES1) on the inbred DBA/1lacJ background. mPGES1-deficient (mPGES1-/-) mice are viable and fertile and develop normally compared with wild-type controls. However, mPGES1-/- mice displayed a marked reduction in inflammatory responses compared with mPGES1+/+ mice in multiple assays. Here, we identify mPGES1 as the PGE synthase that contributes to the pathogenesis of collagen-induced arthritis, a disease model of human rheumatoid arthritis. We also show that mPGES1 is responsible for the production of PGE2 that mediates acute pain during an inflammatory response. These findings suggest that mPGES1 provides a target for the treatment of inflammatory diseases and pain associated with inflammatory states.
Related Links	http://dx.doi.org/10.1073/pnas.1332766100
Ending Page	9049
Page Count	6
Starting Page	9044
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-07-22
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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