NDLI: Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

Content Provider	PubMed Central
Author	Caloca, María J. Zugaza, José L. David, Matallanas Crespo, Piero Bustelo, Xosé R.
Copyright Year	2003
Abstract	Here we describe a new signaling cross-talk between the Vav/Rac1 and Ras pathways that is established through the stimulation of RasGRP1, an exchange factor for Ras subfamily GTPases. This interaction is crucial for Ras activation in lymphoid cells, since this GTPase cannot become activated in the absence of Vav proteins. The activation of RasGRP1 requires both the generation of diacylglycerol via phospho lipase C-γ and the induction of actin polymerization, two responses induced by Vav and Rac1 that facilitate the translocation of RasGRP1 to juxtamembrane areas of the cell. Consistent with this, the cross-talk can be activated by tyrosine-phosphorylated wild-type Vav, oncogenic Vav and constitutively active Rac1. Conversely, Ras activation can be blocked in lymphocytes and ectopic systems using inhibitors affecting either phospholipase C-γ or F-actin polymerization. These results indicate that a relay mechanism exists in lymphoid and other cells helping in the generation of robust signaling responses by the Rac/Rho and Ras pathways upon receptor engagement.
Related Links	http://dx.doi.org/10.1093/emboj/cdg316
Ending Page	3336
Page Count	11
Starting Page	3326
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	13
Volume Number	22
Language	English
Publisher	Oxford University Press
Publisher Date	2003-07-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3

The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission

GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes

p160ROCK mediates RhoA activation of Na-H exchange.

Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex

PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2.

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

Similar Documents

Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3

The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission

GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes

p160ROCK mediates RhoA activation of Na-H exchange.

Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex

PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2.

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1