NDLI: T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells

Content Provider	PubMed Central
Author	Lugo-villarino, Geanncarlo Roberto, Maldonado-lópez Richard, Possemato Peñaranda, Cristina Glimcher, Laurie H.
Copyright Year	2003
Abstract	IFN-γ is well known as the signature cytokine of CD4+ T helper 1, CD8+, and natural killer cells, but recent studies demonstrate that antigen-presenting cells, in particular dendritic cells (DCs), are another potent source for this proinflammatory cytokine. T-bet, a transcription factor that controls IFN-γ expression in CD4+ T cells, was reported recently to be expressed in human monocytes and myeloid DCs. In this study we investigate the role of T-bet in this important cell type. The development, differentiation, and activation of bone marrow and splenic DCs were unimpaired in mice lacking T-bet. However, T-bet was essential for the optimal production of IFN-γ by both CD8α+ and CD8α- DCs. T-bet-deficient DCs were significantly impaired in their capacity to secrete IFN-γ after both stimulation with IL-12 alone or in combination with IL-18. Further, T-bet-/- DCs were impaired in their ability to activate the T helper 1 program of adoptively transferred antigen-specific T cells in vivo. The rapid up-regulation of T-bet by IFN-γ in DCs coupled with a function for DC-derived IFN-γ in T cell activation may constitute a positive feedback loop to maximize type 1 immunity.
Related Links	http://dx.doi.org/10.1073/pnas.1332767100
Ending Page	7754
Page Count	6
Starting Page	7749
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-06-24
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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