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Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone.
| Content Provider | PubMed Central |
|---|---|
| Author | Smith, A. G. Shuster, S. Thody, A. J. Alvarez-ude, F. Kerr, D. N. |
| Abstract | An analysis of the factors that influence the increase in plasma immunoreactive beta-melanocyte-stimulating hormone (beta-MSH) concentration in chronic renal failure showed that: (a) the increase correlated with the increase in serum creatinine concentrations; (b) beta-MSH was not cleared from the plasma by haemodialysis; (c) beta-MSH concentrations increased with length of time on dialysis and increased further after bilateral nephrectomy but there was no further increase with time; (d) beta-MSH levels decreased to normal after renal transplantation; and (e) beta-MSH was excreted in urine only when plasma levels rose to well above those of chronic renal failure (in Nelson's syndrome). These findings suggest that the kidney regulated plasma beta-MSH by a non-excretory mechanism and is the major site of beta-MSH metabolism. |
| Ending Page | 876 |
| Starting Page | 874 |
| File Format | |
| ISSN | 00071447 |
| Journal | British Medical Journal |
| Issue Number | 6014 |
| Volume Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
