NDLI: Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3 − secretion: relevance to cystic fibrosis

Content Provider	PubMed Central
Author	Wang, Youxue Soyombo, Abigail A. Nikolay, Shcheynikov Zeng, Weizhong Dorwart, Michael Marino, Christopher R. Thomas, Philip J. Muallem, Shmuel
Copyright Year	2006
Abstract	Fluid and HCO3 − secretion are vital functions of the pancreatic duct and other secretory epithelia. CFTR and Cl−/HCO3 − exchange activity at the luminal membrane are required for these functions. The molecular identity of the Cl−/HCO3 − exchangers and their relationship with CFTR in determining fluid and HCO3 − secretion are not known. We show here that the Cl−/HCO3 − exchanger slc26a6 controls CFTR activity and ductal fluid and HCO3 − secretion. Unexpectedly, deletion of slc26a6 in mice and measurement of fluid and HCO3 − secretion into sealed intralobular pancreatic ducts revealed that deletion of slc26a6 enhanced spontaneous and decreased stimulated secretion. Remarkably, inhibition of CFTR activity with CFTRinh-172, knock-down of CFTR by siRNA and measurement of CFTR current in WT and slc26a6−/− duct cells revealed that deletion of slc26a6 resulted in dis-regulation of CFTR activity by removal of tonic inhibition of CFTR by slc26a6. These findings reveal the intricate regulation of CFTR activity by slc26a6 in both the resting and stimulated states and the essential role of slc26a6 in pancreatic HCO3 − secretion in vivo.
Related Links	http://dx.doi.org/10.1038/sj.emboj.7601387
Ending Page	5057
Page Count	9
Starting Page	5049
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	21
Volume Number	25
Language	English
Publisher Date	2006-11-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3 − secretion: relevance to cystic fibrosis