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| Content Provider | PubMed Central |
|---|---|
| Author | Delesalle, Cathérine Deprez, Piet Schuurkes, Jan A. J. Lefebvre, Romain A. |
| Copyright Year | 2006 |
| Abstract | The use of human prokinetic drugs in colic horses leads to inconsistent results. This might be related to differences in gastrointestinal receptor populations. The motor effects of 5-hydroxytryptamine (5-HT; serotonin) on the equine mid-jejunum were therefore studied. Longitudinal muscle preparations were set up for isotonic measurement. 5-HT induced tonic contractions with superimposed phasic activity; these responses were not influenced by tetrodotoxin and atropine, suggesting a non-neurogenic, non-cholinergic pathway. The 5-HT receptor antagonists GR 127935 (5-HT1B,D), ketanserin (5-HT2A), SB 204741 (5-HT2B), RS 102221 (5-HT2C), granisetron (5-HT3), GR 113808 (5-HT4) and SB 269970 (5-HT7) had no influence on the 5-HT-induced response; the 5-HT1A receptor antagonists NAN 190 (pK b=8.13±0.06) and WAY 100635 (pK b=8.69±0.07), and the 5-HT1,2,5,6,7 receptor antagonist methysergide concentration-dependently inhibited the 5-HT-induced contractile response. The 5-HT1,7 receptor agonist 5-carboxamidotryptamine (5-CT) induced a contractile response similar to that of 5-HT; its effect was not influenced by tetrodotoxin and atropine, and SB 269970, but antagonised by WAY 100635. 8-OHDPAT, buspiron and flesinoxan, which are active at rat and human 5-HT1A receptors, had no contractile influence. These results suggest that the contractile effect of 5-HT in equine jejunal longitudinal muscle is due to interaction with muscular 5-HT receptors, which cannot be characterised between the actually known classes of 5-HT receptors. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0706431 |
| Ending Page | 35 |
| Page Count | 13 |
| Starting Page | 23 |
| File Format | |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 147 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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