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| Content Provider | PubMed Central |
|---|---|
| Author | Krin, Evelyne Chakroun, Nesrine Turlin, Evelyne Alain, Givaudan Gaboriau, François Bonne, Isabelle Rousselle, Jean-claude Frangeul, Lionel Lacroix, Céline Hullo, Marie-françoise Marisa, Laetitia Danchin, Antoine Sylviane, Derzelle |
| Copyright Year | 2006 |
| Abstract | Bacterial virulence is an integrative process that may involve quorum sensing. In this work, we compared by global expression profiling the wild-type entomopathogenic Photorhabdus luminescens subsp. laumondii TT01 to a luxS-deficient mutant unable to synthesize the type 2 quorum-sensing inducer AI-2. AI-2 was shown to regulate more than 300 targets involved in most compartments and metabolic pathways of the cell. AI-2 is located high in the hierarchy, as it controls the expression of several transcriptional regulators. The regulatory effect of AI-2 appeared to be dose dependent. The luxS-deficient strain exhibited decreased biofilm formation and increased type IV/V pilus-dependent twitching motility. AI-2 activated its own synthesis and transport. It also modulated bioluminescence by regulating the synthesis of spermidine. AI-2 was further shown to increase oxidative stress resistance, which is necessary to overcome part of the innate immune response of the host insect involving reactive oxygen species. Finally, we showed that the luxS-deficient strain had attenuated virulence against the lepidopteran Spodoptera littoralis. We concluded that AI-2 is involved mainly in early steps of insect invasion in P. luminescens. |
| Related Links | http://dx.doi.org/10.1128/aem.00398-06 |
| Ending Page | 6451 |
| Page Count | 13 |
| Starting Page | 6439 |
| File Format | |
| ISSN | 00992240 |
| e-ISSN | 10985336 |
| Journal | Applied and Environmental Microbiology |
| Issue Number | 10 |
| Volume Number | 72 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2006-10-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Biotechnology Food Science Ecology Applied Microbiology and Biotechnology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ecology Food Science Applied Microbiology and Biotechnology Biotechnology |
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