NDLI: β-Amyloid Mediated Nitration of Manganese Superoxide Dismutase

Content Provider	PubMed Central
Author	Anantharaman, Muthuswamy Tangpong, Jitbanjong Keller, Jeffery N. Murphy, Michael P. Markesbery, William R. Kiningham, Kelley K. Clair, Daret K. St
Copyright Year	2006
Abstract	Alzheimer’s disease is a multifactorial, progressive, age-related neurodegenerative disease. In familial Alzheimer’s disease, Aβ is excessively produced and deposited because of mutations in the amyloid precursor protein, presenilin-1, and presenilin-2 genes. Here, we generated a double homozygous knock-in mouse model that incorporates the Swedish familial Alzheimer’s disease mutations and converts mouse Aβ to the human sequence in amyloid precursor protein and had the P264L familial Alzheimer’s disease mutation in presenilin-1. We observed Aβ deposition in double knock-in mice beginning at 6 months as well as an increase in the levels of insoluble Aβ1-40/1-42. Brain homogenates from 3-, 6-, 9-, 12-, and 14-month-old mice showed that protein levels of manganese superoxide dismutase (MnSOD) were unchanged in the double knock-in mice compared to controls. Genotype-associated increases in nitrotyrosine levels were observed. Protein immunoprecipitation revealed MnSOD as a target of this nitration. Although the levels of MnSOD protein did not change, MnSOD activity and mitochondrial respiration decreased in knock-in mice, suggesting compromised mitochondrial function. The compromised activity of MnSOD, a primary antioxidant enzyme protecting mitochondria, may explain mitochondrial dysfunction and provide the missing link between Aβ-induced oxidative stress and Alzheimer’s disease.
Related Links	http://dx.doi.org/10.2353/ajpath.2006.051223
Starting Page	1608
File Format	PDF
ISSN	15252191
e-ISSN	15252191
Journal	The American Journal of Pathology
Issue Number	5
Volume Number	168
Language	English
Publisher	American Society for Investigative Pathology
Publisher Date	2006-05-01
Access Restriction	Open
Rights Holder	American Society for Investigative Pathology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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