NDLI: Vibrio cholerae virulence regulator-coordinated evasion of host immunity

Content Provider	PubMed Central
Author	Hsiao, Ansel Liu, Zhi Adam, Joelsson Zhu, Jun
Copyright Year	2006
Abstract	To successfully propagate and cause disease, pathogenic bacteria must modulate their transcriptional activities in response to pressures exerted by the host immune system, including secreted immunoglobulins such as secretory IgA (S-IgA), which can bind and agglutinate bacteria. Here, we present a previously undescribed flow cytometry-based screening method to identify bacterial genes expressed in vitro and repressed during infections of Vibrio cholerae, an aquatic Gram-negative bacterium responsible for the severe diarrheal disease cholera. We identified a type IV mannose-sensitive hemagglutinin (MSHA) pilus that is repressed specifically in vivo. We showed that bacteria that failed to turn off MSHA biosynthesis were unable to colonize the intestines of infant mice in the presence of S-IgA. We also found that V. cholerae bound S-IgA in an MSHA-dependent and mannose-sensitive fashion and that binding of S-IgA prevented bacteria from penetrating mucus barriers and attaching to the surface of epithelial cells. The ability of V. cholerae to evade the non-antigen-specific binding of S-IgA by down-regulating a surface adhesin represents a previously undescribed mechanism of immune evasion in pathogenic bacteria. In addition, we found that repression of MSHA was mediated by the key virulence transcription factor ToxT, indicating that V. cholerae is able to coordinate both virulence gene activation and repression to evade host defenses and successfully colonize intestines.
Related Links	http://dx.doi.org/10.1073/pnas.0604650103
Ending Page	14547
Page Count	6
Starting Page	14542
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	39
Volume Number	103
Language	English
Publisher	National Academy of Sciences
Publisher Date	2006-09-26
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Vibrio cholerae virulence regulator-coordinated evasion of host immunity.

Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB

TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae

Quorum sensing and a global regulator TsrA control expression of type VI secretion and virulence in Vibrio cholerae

Quorum-sensing regulators control virulence gene expression in Vibrio cholerae

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TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae.

Central metabolism controls transcription of a virulence gene regulator in Vibrio cholerae

Virulence regulator AphB enhances toxR transcription in Vibrio cholerae

Vibrio cholerae virulence regulator-coordinated evasion of host immunity

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Vibrio cholerae virulence regulator-coordinated evasion of host immunity.

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Vibrio cholerae virulence regulator-coordinated evasion of host immunity