NDLI: APC mutations are sufficient for the growth of early colorectal adenomas

Content Provider	PubMed Central
Author	Hanan, Lamlum Papadopoulou, Angeliki Ilyas, Md Rowan, Andrew Gillet, Cheryl Hanby, Andrew Talbot, Ian Bodmer, Walter Tomlinson, Ian
Copyright Year	2000
Abstract	It is not clear whether APC mutations are sufficient for early colorectal adenomas to grow or whether additional mutations at other loci are required. We previously have screened 210 early colorectal adenomas from familial adenomatous polyposis patients for mutations and allelic loss at APC. Here, we determined whether allelic loss at APC had any effect on the nearby α-catenin gene. However, loss on 5q in familial adenomatous polyposis adenomas rarely extended as far as α-catenin, and no differences in α-catenin protein expression were found in tumors that showed loss encompassing both APC and α-catenin. We then screened all 210 tumors for mutations at candidate loci other than APC (K-ras, β-catenin, and allelic loss at 1p33-p35 and 1p36) and for microsatellite instability (MSI). Each of these loci has been implicated previously in early colorectal tumorigenesis. One tumor harbored a β-catenin mutation and another MSI, but none showed K-ras mutation or allelic loss at 1p33-p35 or 1p36. These data support the following hypotheses derived from sporadic colorectal tumors: β-catenin mutations are generally an alternative to mutations at APC, MSI is not usually an early phenomenon in colorectal tumorigenesis, and K-ras mutations are more typical of large- and moderate-sized adenomas. Contrary to some previous reports, chromosome 1p allelic loss is infrequent in very early adenomas. APC mutations are generally sufficient for colorectal tumors to grow to about 1-cm diameter, although chance mutations at other loci can provide these early colorectal adenomas with a selective advantage, and some colorectal tumors may develop along a pathway not involving APC.
Related Links	http://dx.doi.org/10.1073/pnas.040564697
Ending Page	2228
Page Count	4
Starting Page	2225
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	97
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2000-02-29
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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