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| Content Provider | PubMed Central |
|---|---|
| Author | Fu, Li Kaneko, Takeshi Ikeda, Hirotada Nishiyama, Harumi Suzuki, Shunsuke Okubo, Takao Trevisani, Marcello Geppetti, Pierangelo Yoshiaki, Ishigatsubo |
| Copyright Year | 2002 |
| Abstract | Acute exposure to ozone is known to cause airway hyperresponsiveness, which, at least in part, seems to result from an increase in the permeability of the airway mucosa. Recently, we demonstrated that depletion of sensory neuropeptides inhibits the ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs. The aim of this study was to determine whether tachykinins mediate ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs. Anaesthetized guinea-pigs were exposed to either 3 p.p.m. ozone or filtered air for 30 min. Immediately after exposure, a tracheal segment was isolated in vivo and administered with horseradish peroxidase (HRP). The permeability was assessed by monitoring the appearance of HRP in the blood. A low dose of NKA increased the permeability of the tracheal mucosa, whereas a low dose of SP was without effect. Low and high doses of the selective NK3 receptor agonist, senktide, were also without effect. The effect of a low dose of NKA was abolished by the NK2 receptor antagonist, SR-48,968. A high dose of SP increased the permeability in a manner reversible by the NK1 receptor antagonist, CP-96,345. Pretreatment with SR-48,968 completely inhibited the ozone-induced increase in the permeability, whereas CP-96,345 had no effect. It is thus concluded that endogenous tachykinins mediate the ozone-induced increase in the permeability of the tracheal mucosa in guinea-pigs mainly via NK2 receptor activation. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0704572 |
| Ending Page | 1335 |
| Page Count | 5 |
| Starting Page | 1331 |
| File Format | |
| ISSN | 00071188 |
| Journal | British Journal of Pharmacology |
| Issue Number | 5 |
| Volume Number | 135 |
| Language | English |
| Publisher Date | 2002-03-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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