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| Content Provider | PubMed Central |
|---|---|
| Author | Marx, Stephen Vedernikov, Yuri Saade, George R. Garfield, Robert E. |
| Copyright Year | 2000 |
| Abstract | The study was prompted by the report of Ruiz E. & Tejerina T., 1998 describing endothelium-independent relaxation by L-citrulline via activation of particulate guanylate cyclase. We compared the effects of L-citrulline and L-arginine in isolated aortic rings of rats and in isolated aortic, carotid and femoral artery rings of rabbits. No significant relaxation to either L-citrulline or L-arginine was found in the concentration range of 10−12 to 10−3 M, while 3-morpholinosydnonimine hydrochloride (SIN-1, 10−6 M) relaxed vascular tissues. This study does not support the conclusion that L-citrulline has direct vasorelaxing action on vascular smooth muscle. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0703372 |
| Starting Page | 713 |
| File Format | |
| ISSN | 00071188 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 130 |
| Language | English |
| Publisher Date | 2000-06-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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