NDLI: Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity

Content Provider	PubMed Central
Author	Nakayama, Jun-ichi Xiao, Guoping Noma, Ken-ichi Malikzay, Asra Bjerling, Pernilla Ekwall, Karl Kobayashi, Ryuji Grewal, Shiv I. S.
Copyright Year	2003
Abstract	The post-translational modifications of histones are key to the modulation of chromatin structure. Distinct patterns of modifications established by histone-modifying enzymes control diverse chromosomal processes. Here, we report the purification and molecular characterization of the fission yeast Clr6 histone deacetyl ase involved in higher order chromatin assembly. We show that a chromodomain protein Alp13, which belongs to the conserved MRG protein family linked to cellular senescence in humans, is associated with Clr6. In addition, Clr6 interacts with homologs of the mammalian transcriptional co-repressors Sin3, Pst1 and Pst2, and a WD40 repeat-containing protein, Prw1. Alp13, Pst2 and Prw1 form a stable complex with Clr6 in the nucleus. Deletion of any of these factors causes progressive loss of viability and sensitivity to DNA-damaging agents, and impairs condensation/resolution of chromosomes during mitosis. This is accompanied by hyperacetylation of histones and a reduction in histone H3 Ser10 phosphorylation, which correlates with chromosome condensation during mitosis. These results link the MRG family protein Alp13 to histone deacetylation, and suggest that Clr6 and its associated factors are essential for fundamental chromosomal events.
Related Links	http://dx.doi.org/10.1093/emboj/cdg248
Starting Page	2776
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	11
Volume Number	22
Language	English
Publisher	Oxford University Press
Publisher Date	2003-06-02
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity

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Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity