NDLI: Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors

Content Provider	PubMed Central
Author	Sakurada, Tsukasa Katsuyama, Sou Sakurada, Shinobu Inoue, Makoto Tan-no, Koichi Kisara, Kensuke Sakurada, Chikai Ueda, Hiroshi Sasaki, Jun
Copyright Year	1999
Abstract	Intrathecal (i.t.) injection of nociceptin at small doses (fmol order) elicited a behavioural response consisting of scratching, biting and licking in conscious mice. Here we have examined the involvement of substance P-containing neurons by using i.t. injection of tachykinin neurokinin (NK)1 receptor antagonists and substance P (SP) antiserum. Nociceptin-induced behavioural response was evoked significantly 5–10 min after i.t. injection and reached a maximum at 10–15 min. Dose-dependency of the induced response showed a bell-shaped pattern from 0.375–30.0 fmol, and the maximum effect was observed at 3.0 fmol. The behavioural response elicited by nociceptin (3.0 fmol) was dose-dependently inhibited by intraperitoneal (i.p.) administration of morphine. The NK1 receptor antagonists, CP-96,345, CP-99,994 and sendide, inhibited nociceptin-induced behavioural response in a dose-dependent manner. A significant antagonistic effect of [D-Phe7, D-His9]SP (6–11), a selective antagonist for SP receptors, was observed against nociceptin-induced response. The NK2 receptor antagonist, MEN-10376, had no effect on the response elicited by nociceptin. Pretreatment with SP antiserum resulted in a significant reduction of the response to nociceptin. No significant reduction of nociceptin-induced response was detected in mice pretreated with NKA antiserum. The N-methyl-D-aspartate (NMDA) receptor antagonists, dizocilpine (MK-801) and D(−)-2-amino-5-phosphonovaleric acid (APV) (D-APV), and L-NG-nitro arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, failed to inhibit nociceptin-induced behavioural response. The present results suggest that SP-containing neurons in the mouse spinal cord may be involved in elicitation of scratching, biting and licking behaviour following i.t. injection of nociceptin.
Related Links	http://dx.doi.org/10.1038/sj.bjp.0702698
Ending Page	1718
Page Count	7
Starting Page	1712
File Format	PDF
ISSN	00071188
Journal	British Journal of Pharmacology
Issue Number	7
Volume Number	127
Language	English
Publisher Date	1999-08-01
Access Restriction	Open
Subject Keyword	Pharmacology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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