NDLI: Interaction of amiodarone and triiodothyronine on the expression of β-adrenoceptors in brown adipose tissue of rat

Content Provider	PubMed Central
Author	Adli, Houria Bazin, Raymond Perret, Gérard Y.
Copyright Year	1999
Abstract	This study was undertaken to evaluate in vivo the influence of amiodarone on the effects of triiodothyronine (T3) in brown adipose tissue (BAT) which are independent of thyroid hormone synthesis and of the conversion of thyroxine (T4) to T3. Thyroidectomized rats were given a replacement dose of T3 (0.5 mg kg−1 p.o. daily for 3 days) with or without amiodarone (50 mg kg−1 p.o. daily for 1 week). As assessed by RT–PCR, treatment of thyroidectomized rats with T3 caused a 2 fold decrease in β3-adrenoceptor (β3-AR) mRNA levels and a 2 fold increase in β1-AR mRNA levels. Binding studies using [3H]-CGP 12177 as a ligand showed that treatment of thyoidectomized rats with T3 resulted in a 70% decrease in β3-AR number and in an 80% increase in β1-AR in BAT membranes. T3-treatment abolished the increase in BAT adenylyl cyclase (AC) activity induced by CGP12177 in thyroidectomized rats. It also decreased the amount of Gi protein (ADP-ribosylation) by 30%. At variance with the literature on the heart, amiodarone administration did not inhibit the positive effect of T3 on β1-AR expression in BAT in thyroidectomized rats. However, it antagonized the effect of T3 on β3-AR number, but not on AC activity or on Gi expression. These results indicate that the effects of thyroid hormones on the responsiveness of BAT to catecholamines involves both receptor and post-receptor mechanisms, they also suggest that interaction between amiodarone and thyroid hormones is highly tissue-specific and depends on the β-AR subtype.
Related Links	http://dx.doi.org/10.1038/sj.bjp.0702456
Ending Page	1461
Page Count	7
Starting Page	1455
File Format	PDF
ISSN	00071188
Journal	British Journal of Pharmacology
Issue Number	6
Volume Number	126
Language	English
Publisher Date	1999-03-01
Access Restriction	Open
Subject Keyword	Pharmacology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interaction of amiodarone and triiodothyronine on the expression of beta-adrenoceptors in brown adipose tissue of rat.

Further evidence for differences between cardiac atypical β-adrenoceptors and brown adipose tissue β3-adrenoceptors in the pithed rat

Further evidence for differences between cardiac atypical beta-adrenoceptors and brown adipose tissue beta3-adrenoceptors in the pithed rat.

Ligand binding properties of putative beta 3-adrenoceptors compared in brown adipose tissue and in skeletal muscle membranes.

Atypical β-adrenoceptors, different from β 3-adrenoceptors and probably from the low-affinity state of β 1-adrenoceptors, relax the rat isolated mesenteric artery

An In Vitro Effect of Triiodothyronine on Rat Adipose Tissue *

Differential regulation of β 3-adrenoceptors in gut and adipose tissue of genetically obese (ob/ob) C57BL/6J-mice

Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.

Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.

Interaction of amiodarone and triiodothyronine on the expression of β-adrenoceptors in brown adipose tissue of rat

Similar Documents

Interaction of amiodarone and triiodothyronine on the expression of beta-adrenoceptors in brown adipose tissue of rat.

Further evidence for differences between cardiac atypical β-adrenoceptors and brown adipose tissue β3-adrenoceptors in the pithed rat

Further evidence for differences between cardiac atypical beta-adrenoceptors and brown adipose tissue beta3-adrenoceptors in the pithed rat.

Ligand binding properties of putative beta 3-adrenoceptors compared in brown adipose tissue and in skeletal muscle membranes.

Atypical β-adrenoceptors, different from β 3-adrenoceptors and probably from the low-affinity state of β 1-adrenoceptors, relax the rat isolated mesenteric artery

An In Vitro Effect of Triiodothyronine on Rat Adipose Tissue *

Differential regulation of β 3-adrenoceptors in gut and adipose tissue of genetically obese (ob/ob) C57BL/6J-mice

Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.

Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.

Interaction of amiodarone and triiodothyronine on the expression of β-adrenoceptors in brown adipose tissue of rat