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| Content Provider | PubMed Central |
|---|---|
| Author | Hall, Judith M. Brain, Susan D. |
| Copyright Year | 1999 |
| Abstract | This study used intravital microscopy to investigate the receptors stimulated by amylin which shares around 50% sequence homology with the vasodilator calcitonin gene-related peptide (CGRP) in the hamster cheek pouch microvasculature in vivo. Receptor agonists dilated arterioles (diameters 20–40 μm). The −log of the concentrations (±s.e.mean; n=8) causing 50% increase in arteriole diameter were: human βCGRP (10.8±0.3), human αCGRP (10.8±0.4), rat αCGRP (10.4±0.3). Rat amylin and the CGRP2 receptor selective agonist [Cys(ACM2,7]-human αCGRP were 100 fold less potent (estimates were 8.5±0.4 and 8.2±0.3 respectively). The GCRP1 receptor antagonist, CGRP8–37 (300 nmol kg−1; i.v.) reversibly inhibited the increase in diameter evoked by human αCGRP (0.3 nM) from 178±22% to 59±12% (n=8; P<0.05) and by rat amylin (100 nM) from 138±23% to 68±24% (n=6; P<0.05). CGRP8–37 did not inhibit vasodilation evoked by substance P (10 nM; n=4; P>0.05). The amylin receptor antagonist, amylin8–37 (300 nmol kg−1; i.v.) did not significantly inhibit the increase in diameter evoked by human αCGRP (0.3 nM) which was 112±26% in the absence, and 90±29% in the presence of antagonist (n=4; P<0.05); nor that evoked by rat amylin (100 nM) which was 146±23% in the absence and 144±32% in the presence of antagonist (n=4; P>0.05). The agonist profile for vasodilatation and the inhibition of this dilatation by CGRP8–37, although not the amylin8–37 indicates that amylin causes vasodilatation through interaction with CGRP1 receptors in the hamster cheek pouch. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0702272 |
| Starting Page | 280 |
| File Format | |
| ISSN | 00071188 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 126 |
| Language | English |
| Publisher Date | 1999-01-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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