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| Content Provider | PubMed Central |
|---|---|
| Author | Elena, Chertova Chertov, Oleg Coren, Lori V. Roser, James D. Trubey, Charles M. Bess, Julian W. Sowder, Raymond C. Barsov, Eugene Hood, Brian L. Fisher, Robert J. Nagashima, Kunio Conrads, Thomas P. Veenstra, Timothy D. Lifson, Jeffrey D. Ott, David E. |
| Copyright Year | 2006 |
| Abstract | Human immunodeficiency virus type 1 (HIV-1) infects CD4+ T lymphocytes and monocytes/macrophages, incorporating host proteins in the process of assembly and budding. Analysis of the host cell proteins incorporated into virions can provide insights into viral biology. We characterized proteins in highly purified HIV-1 virions produced from human monocyte-derived macrophages (MDM), within which virus buds predominantly into intracytoplasmic vesicles, in contrast to the plasmalemmal budding of HIV-1 typically seen with infected T cells. Liquid chromatography-linked tandem mass spectrometry of highly purified virions identified many cellular proteins, including 33 previously described proteins in HIV-1 preparations from other cell types. Proteins involved in many different cellular structures and functions were present, including those from the cytoskeleton, adhesion, signaling, intracellular trafficking, chaperone, metabolic, ubiquitin/proteasomal, and immune response systems. We also identified annexins, annexin-binding proteins, Rab proteins, and other proteins involved in membrane organization, vesicular trafficking, and late endosomal function, as well as apolipoprotein E, which participates in cholesterol transport, immunoregulation, and modulation of cell growth and differentiation. Several tetraspanins, markers of the late endosomal compartment, were also identified. MDM-derived HIV contained 26 of 37 proteins previously found in exosomes, consistent with the idea that HIV uses the late endosome/multivesicular body pathway during virion budding from macrophages. |
| Related Links | http://dx.doi.org/10.1128/jvi.01013-06 |
| Ending Page | 9052 |
| Page Count | 14 |
| Starting Page | 9039 |
| File Format | |
| ISSN | 0022538X |
| e-ISSN | 10985514 |
| Journal | Journal of Virology |
| Issue Number | 18 |
| Volume Number | 80 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2006-09-15 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Virology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology Insect Science |
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