NDLI: The flagellar-specific transcription factor, σ28, is the Type III secretion chaperone for the flagellar-specific anti-σ28 factor FlgM

Content Provider	PubMed Central
Author	Aldridge, Phillip D. Karlinsey, Joyce E. Aldridge, Christine Birchall, Christopher Thompson, Danielle Jin, Yagasaki Hughes, Kelly T.
Copyright Year	2006
Abstract	The σ28 protein is a member of the bacterial σ70-family of transcription factors that directs RNA polymerase to flagellar late (class 3) promoters. The σ28 protein is regulated in response to flagellar assembly by the anti-σ28 factor FlgM. FlgM inhibits σ28-dependent transcription of genes whose products are needed late in assembly until the flagellar basal motor structure, the hook-basal body (HBB), is constructed. A second function for the σ28 transcription factor has been discovered: σ28 facilitates the secretion of FlgM through the HBB, acting as the FlgM Type III secretion chaperone. Transcription-specific mutants in σ28 were isolated that remained competent for FlgM-facilitated secretion separating the transcription and secretion-facilitation activities of σ28. Conversely, we also describe the isolation of mutants in σ28 that are specific for FlgM-facilitated secretion. The data demonstrate that σ28 is the Type III secretion chaperone for its own anti-sigma factor FlgM. Thus, a novel role for a σ70-family transcription factor is described.
Related Links	http://dx.doi.org/10.1101/gad.380406
Starting Page	2315
File Format	PDF
ISSN	08909369
Journal	Genes & Development
Issue Number	16
Volume Number	20
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2006-08-15
Access Restriction	Open
Rights Holder	Cold Spring Harbor Laboratory Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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