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| Content Provider | PubMed Central |
|---|---|
| Author | Yonashiro, Ryo Ishido, Satoshi Kyo, Shinkou Fukuda, Toshifumi Goto, Eiji Matsuki, Yohei Mari, Ohmura-hoshino Sada, Kiyonao Hotta, Hak Yamamura, Hirohei Inatome, Ryoko Yanagi, Shigeru |
| Copyright Year | 2006 |
| Abstract | In this study, we have identified a novel mitochondrial ubiquitin ligase, designated MITOL, which is localized in the mitochondrial outer membrane. MITOL possesses a Plant Homeo-Domain (PHD) motif responsible for E3 ubiquitin ligase activity and predicted four-transmembrane domains. MITOL displayed a rapid degradation by autoubiquitination activity in a PHD-dependent manner. HeLa cells stably expressing a MITOL mutant lacking ubiquitin ligase activity or MITOL-deficient cells by small interfering RNA showed an aberrant mitochondrial morphology such as fragmentation, suggesting the enhancement of mitochondrial fission by MITOL dysfunction. Indeed, a dominant-negative expression of Drp1 mutant blocked mitochondrial fragmentation induced by MITOL depletion. We found that MITOL associated with and ubiquitinated mitochondrial fission protein hFis1 and Drp1. Pulse–chase experiment showed that MITOL overexpression increased turnover of these fission proteins. In addition, overexpression phenotype of hFis1 could be reverted by MITOL co-overexpression. Our finding indicates that MITOL plays a critical role in mitochondrial dynamics through the control of mitochondrial fission proteins. |
| Related Links | http://dx.doi.org/10.1038/sj.emboj.7601249 |
| Ending Page | 3626 |
| Page Count | 9 |
| Starting Page | 3618 |
| File Format | |
| ISSN | 02614189 |
| e-ISSN | 14602075 |
| Journal | The EMBO Journal |
| Issue Number | 15 |
| Volume Number | 25 |
| Language | English |
| Publisher Date | 2006-08-09 |
| Access Restriction | Open |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Immunology and Microbiology Medicine Molecular Biology |
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