NDLI: Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats

Please wait, while we are loading the content...

Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction

Effects of angiotensin II on connexin 43 of VSMCs in arteriosclerosis

A new local ablation for unresectable primary liver tumor: effect of electrothermal and electrochemical therapy on rat liver

Immunogenicity of formaldehyde and binary ethylenimine inactivated infectious bursal disease virus in broiler chicks*

Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea*

A clinical study of the efficacy of topical corticosteroids on dry eye

High density porous polyethylene material (Medpor) as an unwrapped orbital implant

Year: 2006, Volume: 7, Issue: 7

Year: 2006, Volume: 7, Issue: 6

Year: 2006, Volume: 7, Issue: 5

Year: 2006, Volume: 7, Issue: 4

Year: 2006, Volume: 7, Issue: 3

Year: 2006, Volume: 7, Issue: 2

Year: 2006, Volume: 7, Issue: 1

Year: 2005, Volume: 6

Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats

Content Provider	PubMed Central
Author	Xu, Ping Zhang, Xing-guo Li, You-ming Yu, Chao-hui Xu, Lei Xu, Gen-yun
Copyright Year	2006
Abstract	Objective: The prevalence of non-alcoholic fatty liver disease (NAFLD) has markedly increased. Insulin resistance has been implicated in the pathogenesis of NAFLD. This study was aimed at observing the relationship between insulin resistance and NAFLD, and evaluating the role of pioglitazone (PGZ) acting as insulin-sensitizing agents in the prevention and treatment of rat fatty liver induced by high fat feeding. Methods: The rats were separated randomly into 6 groups: model group I were fed high fat diet for 8 weeks, PGZ prevention group were given PGZ 4 mg/(kg·d) simultaneously, while control group I were fed normal food for 8 weeks; model group II were fed high fat diet for 16 weeks, PGZ treatment group were given PGZ 4 mg/(kg·d) orally simultaneous with high fat diet for 8 weeks after high fat feeding for 8 weeks, control group II were fed normal food for 16 weeks. The rats were sacrificed after 8 weeks and 16 weeks respectively. Liver weight, body weight, serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), tumor necrosis factor alpha (TNF-α), fasting blood glucose (FBG), fasting plasma insulin (FINS), HOMA (homeostasis model assessment) insulin resistance index (HOMA-IR), and the liver histology of rats of all groups were assayed. Results: After 8 weeks, the liver in model group I showed typical steatosis, accompanied with mild to moderate lobular inflammatory cell infiltration, liver indexes and serum levels of ALT, AST, ALP, TNF-α were significantly increased (P<0.05) compared with control group I. Whereas, the degree of hepatic injury was attenuated in PGZ prevention group, liver indexes and serum levels of ALT, ALP were significantly decreased (P<0.05) compared with model group I. After 16 weeks, notable steatosis, and lobular inflammation were observed in model group II rat liver, while the degree of hepatic injury was attenuated in the PGZ treatment group. Liver index, serum levels of ALT, AST, ALP, FINS and HOMA-IR were significantly increased (P<0.05) in model group II compared with control group II. Whereas, in PGZ treatment group, serum levels of AST and FINS showed decreasing tendency, liver indexes, serum levels of ALT, ALP, TNF-α and HOMA-IR were significantly decreased compared with model group II. Conclusion: Insulin resistance plays a role in the pathogenesis of NAFLD in rats. Pioglitazone can attenuate insulin resistance and biochemical and histological injury in high fat-induced fatty liver in rats.
Related Links	http://dx.doi.org/10.1631/jzus.2006.b0627
Ending Page	633
Page Count	7
Starting Page	627
File Format	PDF
ISSN	16731581
Journal	Journal of Zhejiang University. Science. B
Issue Number	8
Volume Number	7
Language	English
Publisher	Zhejiang University Press
Publisher Date	2006-08-01
Access Restriction	Open
Rights Holder	Zhejiang University Press
Subject Keyword	Pharmacology, Toxicology and Pharmaceutics(all) Biochemistry, Genetics and Molecular Biology(all) veterinary(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats

Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats.

Effect of dietary fatty acids on serum parameters, fatty acid compositions, and liver histology in Shaoxing laying ducks*

Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD

Th17 promotes acute rejection following liver transplantation in rats*

Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats

Metformin in non-alcoholic fatty liver disease: A systematic review and meta-analysis

Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli*

Dual liver transplantation*

Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats

Similar Documents

Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats

Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats.

Effect of dietary fatty acids on serum parameters, fatty acid compositions, and liver histology in Shaoxing laying ducks*

Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD

Th17 promotes acute rejection following liver transplantation in rats*

Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats

Metformin in non-alcoholic fatty liver disease: A systematic review and meta-analysis

Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli*

Dual liver transplantation*

Research on the protection effect of pioglitazone for non-alcoholic fatty liver disease (NAFLD) in rats