NDLI: Saccharomyces cerevisiae Donor Preference During Mating-Type Switching Is Dependent on Chromosome Architecture and Organization

Content Provider	PubMed Central
Author	Eric, Coïc Richard, Guy-franck Haber, James E.
Copyright Year	2006
Abstract	Saccharomyces mating-type (MAT) switching occurs by gene conversion using one of two donors, HMLα and HMR a, located near the ends of the same chromosome. MAT a cells preferentially choose HMLα, a decision that depends on the recombination enhancer (RE) that controls recombination along the left arm of chromosome III (III-L). When RE is inactive, the two chromosome arms constitute separate domains inaccessible to each other; thus HMR a, located on the same arm as MAT, becomes the default donor. Activation of RE increases HMLα usage, even when RE is moved 50 kb closer to the centromere. If MAT is inserted into the same domain as HML, RE plays little or no role in activating HML, thus ruling out any role for RE in remodeling the silent chromatin of HML in regulating donor preference. When the donors MAT and RE are moved to chromosome V, RE increases HML usage, but the inaccessibility of HML without RE apparently depends on other chromosome III-specific sequences. Similar conclusions were reached when RE was placed adjacent to leu2 or arg4 sequences engaged in spontaneous recombination. We propose that RE's targets are anchor sites that tether chromosome III-L in MATα cells thus reducing its mobility in the nucleus.
Related Links	http://dx.doi.org/10.1534/genetics.106.055392
Ending Page	1206
Page Count	10
Starting Page	1197
File Format	PDF
ISSN	00166731
Journal	Genetics
Issue Number	3
Volume Number	173
Language	English
Publisher	Copyright © 2006 by the Genetics Society of America
Publisher Date	2006-04-01
Access Restriction	Open
Rights Holder	Copyright © 2006 by the Genetics Society of America
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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