NDLI: Evolutionary Relationships among Strains of Mycobacterium tuberculosis with Few Copies of IS6110

Content Provider	PubMed Central
Author	Dale, Jeremy W. Hasan, Al-ghusein Salim, Al-hashmi Butcher, Philip Dickens, Anne L. Francis, Drobniewski Forbes, Ken J. Gillespie, Stephen H. Lamprecht, Dianie Mchugh, Timothy D. Pitman, Richard Rastogi, Nalin Smith, Andrew T. Sola, Christophe Hasan, Yesilkaya
Copyright Year	2003
Abstract	Molecular typing of Mycobacterium tuberculosis by using IS6110 shows low discrimination when there are fewer than five copies of the insertion sequence. Using a collection of such isolates from a study of the epidemiology of tuberculosis in London, we have shown a substantial degree of congruence between IS6110 patterns and both spoligotype and PGRS type. This indicates that the IS6110 types mainly represent distinct families of strains rather than arising through the convergent insertion of IS6110 into favored positions. This is supported by identification of the genomic sites of the insertion of IS6110 in these strains. The combined data enable identification of the putative evolutionary relationships of these strains, comprising three lineages broadly associated with patients born in South Asia (India and Pakistan), Africa, and Europe, respectively. These lineages appear to be quite distinct from M. tuberculosis isolates with multiple copies of IS6110.
Related Links	http://dx.doi.org/10.1128/jb.185.8.2555-2562.2003
Ending Page	2562
Page Count	8
Starting Page	2555
File Format	PDF
ISSN	00219193
e-ISSN	10985530
Journal	Journal of Bacteriology
Issue Number	8
Volume Number	185
Language	English
Publisher	American Society for Microbiology
Publisher Date	2003-04-15
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Molecular Biology Microbiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Microbiology

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