NDLI: Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance

Content Provider	PubMed Central
Author	Earley, Keith Lawrence, Richard J. Pontes, Olga Reuther, Rachel Enciso, Angel J. Silva, Manuela Neves, Nuno Gross, Michael Viegas, Wanda Pikaard, Craig S.
Copyright Year	2006
Abstract	Nucleolar dominance describes the silencing of one parental set of ribosomal RNA (rRNA) genes in a genetic hybrid, an epigenetic phenomenon that occurs on a scale second only to X-chromosome inactivation in mammals. An RNA interference (RNAi) knockdown screen revealed that the predicted Arabidopsis histone deacetylase, HDA6, is required for rRNA gene silencing in nucleolar dominance. In vivo, derepression of silenced rRNA genes upon knockdown of HDA6 is accompanied by nucleolus organizer region (NOR) decondensation, loss of promoter cytosine methylation, and replacement of histone H3 Lys 9 (H3K9) dimethylation with H3K4 trimethylation, H3K9 acetylation, H3K14 acetylation, and histone H4 tetra-acetylation. Consistent with these in vivo results, purified HDA6 deacetylates lysines modified by histone acetyltransferases whose substrates include H3K14, H4K5, and H4K12. HDA6 localizes, in part, to the nucleolus, supporting a model whereby HDA6 erases histone acetylation as a key step in an epigenetic switch mechanism that silences rRNA genes through concerted histone and DNA modifications.
Related Links	http://dx.doi.org/10.1101/gad.1417706
Ending Page	1293
Page Count	11
Starting Page	1283
File Format	PDF
ISSN	08909369
Journal	Genes & Development
Issue Number	10
Volume Number	20
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2006-05-15
Access Restriction	Open
Rights Holder	Cold Spring Harbor Laboratory Press
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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