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| Content Provider | PubMed Central |
|---|---|
| Author | Taylor, P. M. Askonas, B. A. |
| Abstract | Influenza nucleoprotein (NP) serves as a target antigen on abortively infected cells for cytotoxic T cells (Tc) cross-reactive for all type A influenza viruses, and it can also prime mice for such Tc. It is important to test the protective ability of NP-specific Tc clones in vivo in a productive influenza infection. In this report, we show that Tc clones of this antigenic specificity protect mice against a lethal influenza infection on transfer to syngeneic recipients, and also that they reduce virus titres in the lungs and trachea of mice challenged with homologous or heterologous type A influenza viruses. Simultaneous injection of IL-2 to maintain the viability of the Tc clones is not essential, but has made the clonal transfer experiments highly reproducible. |
| Starting Page | 417 |
| File Format | |
| ISSN | 13652567 |
| e-ISSN | 13652567 |
| Journal | Immunology |
| Issue Number | 3 |
| Volume Number | 58 |
| Language | English |
| Publisher Date | 1986-07-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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