NDLI: Quantitative Trait Loci (QTL) Detection in Multicross Inbred Designs

Content Provider	PubMed Central
Author	Sébastien, Crepieux Lebreton, Claude Servin, Bertrand Gilles, Charmet
Copyright Year	2004
Abstract	Mapping quantitative trait loci in plants is usually conducted using a population derived from a cross between two inbred lines. The power of such QTL detection and the parameter estimates depend largely on the choice of the two parental lines. Thus, the QTL detected in such populations represent only a small part of the genetic architecture of the trait. In addition, the effects of only two alleles are characterized, which is of limited interest to the breeder, while common pedigree breeding material remains unexploited for QTL mapping. In this study, we extend QTL mapping methodology to a generalized framework, based on a two-step IBD variance component approach, applicable to any type of breeding population obtained from inbred parents. We then investigate with simulated data mimicking conventional breeding programs the influence of different estimates of the IBD values on the power of QTL detection. The proposed method would provide an alternative to the development of specifically designed recombinant populations, by utilizing the genetic variation actually managed by plant breeders. The use of these detected QTL in assisting breeding would thus be facilitated.
Related Links	http://dx.doi.org/10.1534/genetics.104.028993
Ending Page	1749
Page Count	13
Starting Page	1737
File Format	PDF
ISSN	00166731
Journal	Genetics
Issue Number	3
Volume Number	168
Language	English
Publisher	Genetics Society of America
Publisher Date	2004-11-01
Access Restriction	Open
Rights Holder	Genetics Society of America
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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