NDLI: Hydrops Fetalis, Cardiovascular Defects, and Embryonic Lethality in Mice Lacking the Calcitonin Receptor-Like Receptor Gene

Content Provider	PubMed Central
Author	Dackor, Ryan T. Kimberly, Fritz-six Dunworth, William P. Gibbons, Carrie L. Smithies, Oliver Caron, Kathleen M.
Copyright Year	2006
Abstract	Adrenomedullin (AM) is a multifunctional peptide vasodilator that is essential for life. To date, numerous in vitro studies have suggested that AM can mediate its biological effects through at least three different receptors. To determine the in vivo importance of the most likely candidate receptor, calcitonin receptor-like receptor, a gene-targeted knockout model of the gene was generated. Mice heterozygous for the targeted Calcrl allele appear normal, survive to adulthood, and reproduce. However, heterozygote matings fail to produce viable Calcrl −/− pups, demonstrating that Calcrl is essential for survival. Timed matings confirmed that Calcrl −/− embryos die between embryonic day 13.5 (E13.5) and E14.5 of gestation. The Calcrl −/− embryos exhibit extreme hydrops fetalis and cardiovascular defects, including thin vascular smooth muscle walls and small, disorganized hearts remarkably similar to the previously characterized AM −/− phenotype. In vivo assays of cellular proliferation and apoptosis in the hearts and vasculature of Calcrl −/− and AM −/− embryos support the concept that AM signaling is a crucial mediator of cardiovascular development. The Calcrl gene targeted mice provide the first in vivo genetic evidence that CLR functions as an AM receptor during embryonic development.
Related Links	http://dx.doi.org/10.1128/mcb.26.7.2511-2518.2006
Ending Page	2518
Page Count	8
Starting Page	2511
File Format	PDF
ISSN	02707306
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	7
Volume Number	26
Language	English
Publisher	American Society for Microbiology
Publisher Date	2006-04-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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