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| Content Provider | PubMed Central |
|---|---|
| Author | Heidelberger, M. Tyler, Jean M. Mukherjee, S. |
| Abstract | Although ketha gum has been reported to contain arabinose, galactose, xylose, an unidentified neutral sugar and glucuronic acid, its marked cross-reaction with Type I antipneumococcal horse sera led to the conclusion that D-galacturonic acid must be an additional component. The capsular polysaccharide of Type I pneumococcus, the determinant of immunological specificity, consists of more than 50 per cent of D-galacturonic acid. Chromatography of hydrolysates of ketha gum confirmed the presence of arabinose, galactose and xylose, and furnished spots with the mobilities of galacturonic and 4-O-methylglucuronic acids. Traces of glucuronic acid appeared only under conditions such that demethylation of the 4-O-methyl acid might have occurred. Hydrolysis of larger amounts furnished D-galacturonic acid, as yet syrupy, [α]D+32° instead of +51°, and 4-O-methyl-D-glucuronic acid, [α]D+20° instead of +35°. The latter, especially if present as non-reducing end-groups, would account for the strong precipitation of ketha gum in Type II antipneumococcal horse sera. When ketha gum was esterified, reduced and hydrolysed, the two acids disappeared almost entirely, a component corresponding to 4-O-methylglucose was observed, and the hexose content was increased. Oxidation of the gum with periodate, followed by reduction and hydrolysis, caused the disappearance of the 4-O-methylglucuronic acid and most of the galacturonic acid. Comparison of analyses and chromatograms of the original gum with those of samples recovered from the specific precipitates with Types I and II antisera showed little or no fractionation. |
| Starting Page | 666 |
| File Format | |
| ISSN | 13652567 |
| e-ISSN | 13652567 |
| Journal | Immunology |
| Issue Number | 6 |
| Volume Number | 5 |
| Language | English |
| Publisher Date | 1962-11-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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