NDLI: A Novel Staphylococcus aureus Vaccine: Iron Surface Determinant B Induces Rapid Antibody Responses in Rhesus Macaques and Specific Increased Survival in a Murine S. aureus Sepsis Model

Content Provider	PubMed Central
Author	Kuklin, Nelly A. Clark, Desmond J. Secore, Susan Cook, James Cope, Leslie D. Mcneely, Tessie Noble, Liliane Brown, Martha J. Zorman, Julie K. Wang, Xin Min Gregory, Pancari Fan, Hongxia Isett, Kevin Burgess, Bruce Bryan, Janine Brownlow, Michelle George, Hugh Maria, Meinz Liddell, Mary E. Kelly, Rosemarie Schultz, Loren Montgomery, Donna Onishi, Janet Losada, Maria Martin, Melissa Ebert, Timothy Tan, Charles Y. Schofield, Timothy L. Nagy, Eszter Meineke, Andreas Joyce, Joseph G. Kurtz, Myra B. Caulfield, Michael J. Jansen, Kathrin U. Mcclements, William Anderson, Annaliesa S.
Copyright Year	2006
Abstract	Staphylococcus aureus is a major cause of nosocomial infections worldwide, and the rate of resistance to clinically relevant antibiotics, such as methicillin, is increasing; furthermore, there has been an increase in the number of methicillin-resistant S. aureus community-acquired infections. Effective treatment and prevention strategies are urgently needed. We investigated the potential of the S. aureus surface protein iron surface determinant B (IsdB) as a prophylactic vaccine against S. aureus infection. IsdB is an iron-sequestering protein that is conserved in diverse S. aureus clinical isolates, both methicillin resistant and methicillin sensitive, and it is expressed on the surface of all isolates tested. The vaccine was highly immunogenic in mice when it was formulated with amorphous aluminum hydroxyphosphate sulfate adjuvant, and the resulting antibody responses were associated with reproducible and significant protection in animal models of infection. The specificity of the protective immune responses in mice was demonstrated by using an S. aureus strain deficient for IsdB and HarA, a protein with a high level of identity to IsdB. We also demonstrated that IsdB is highly immunogenic in rhesus macaques, inducing a more-than-fivefold increase in antibody titers after a single immunization. Based on the data presented here, IsdB has excellent prospects for use as a vaccine against S. aureus disease in humans.
Related Links	http://dx.doi.org/10.1128/iai.74.4.2215-2223.2006
Ending Page	2223
Page Count	9
Starting Page	2215
File Format	PDF
ISSN	00199567
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	4
Volume Number	74
Language	English
Publisher	American Society for Microbiology
Publisher Date	2006-04-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

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