NDLI: NMDA receptors are expressed in oligodendrocytes and activated in ischaemia

Content Provider	PubMed Central
Author	Káradóttir, Ragnhildur Cavelier, Pauline Bergersen, Linda H. Attwell, David
Abstract	Glutamate-mediated damage to oligodendrocytes contributes to mental or physical impairment in periventricular leukomalacia (pre- or perinatal white matter injury leading to cerebral palsy), spinal cord injury, multiple sclerosis and stroke1–4. Unlike neurons5, white matter oligodendrocytes reportedly lack NMDA receptors6,7 and it is believed that glutamate damages oligodendrocytes, especially their precursor cells, by acting only on calcium-permeable AMPA/kainate receptors1–4 or by reversing cystine-glutamate exchange and depriving cells of antioxidant protection8. We now show that precursor, immature and mature oligodendrocytes in the white matter of the cerebellum and corpus callosum exhibit NMDA evoked currents, mediated by receptors which are blocked only weakly by Mg2+, which may contain NR1, NR2C and NR3 subunits. NMDA receptors are present in the myelinating processes of oligodendrocytes, where the small intracellular space could lead to a large rise of intracellular ion concentration in response to NMDA receptor activation. Simulating ischaemia led to an inward current developing in oligodendrocytes, which was partly mediated by NMDA receptors. These results point to NMDA receptors of unusual subunit composition as a novel therapeutic target for preventing white matter damage in a range of diseases.
Related Links	http://dx.doi.org/10.1038/nature04302
Ending Page	1166
Page Count	5
Starting Page	1162
File Format	PDF
ISSN	00280836
e-ISSN	14764687
Journal	Nature
Issue Number	7071
Volume Number	438
Language	English
Publisher Date	2005-12-22
Access Restriction	Open
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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