NDLI: Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis

Content Provider	PubMed Central
Author	De, Veylr Lieven Beeckman, Tom Beemster, Gerrit T. S. Krols, Luc Terras, Franky Landrieu, Isabelle Schueren, Els Van Der Maes, Sara Naudts, Mirande Inzé, Dirk
Copyright Year	2001
Abstract	Cyclin-dependent kinase inhibitors, such as the mammalian p27Kip1 protein, regulate correct cell cycle progression and the integration of developmental signals with the core cell cycle machinery. These inhibitors have been described in plants, but their function remains unresolved. We have isolated seven genes from Arabidopsis that encode proteins with distant sequence homology with p27Kip1, designated Kip-related proteins (KRPs). The KRPs were characterized by their domain organization and transcript profiles. With the exception of KRP5, all presented the same cyclin-dependent kinase binding specificity. When overproduced, KRP2 dramatically inhibited cell cycle progression in leaf primordia cells without affecting the temporal pattern of cell division and differentiation. Mature transgenic leaves were serrated and consisted of enlarged cells. Although the ploidy levels in young leaves were unaffected, endoreduplication was suppressed in older leaves. We conclude that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation.
Related Links	http://dx.doi.org/10.1105/TPC.010087
Starting Page	1653
File Format	PDF
ISSN	1532298X
e-ISSN	1532298X
Journal	The Plant Cell
Issue Number	7
Volume Number	13
Language	English
Publisher	American Society of Plant Biologists
Publisher Date	2001-07-01
Access Restriction	Open
Rights Holder	American Society of Plant Biologists
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Plant Science

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