NDLI: Pulmonary Vβ4+ T Cells from Histoplasma capsulatum-Infected Mice Respond to a Homologue of Sec31 That Confers a Protective Response

Content Provider	PubMed Central
Author	Scheckelhoff, Mark R. Deepe, George S.
Abstract	The population of Vβ4+ T cells expands in the lungs of C57BL/6 mice infected with Histoplasma capsulatum, and the elimination of these cells impairs protective immunity. To determine the antigen or antigens that trigger their proliferation, Vβ4+ T cell hybridomas were generated from the lungs and spleens of infected mice. We mapped the antigenic determinants by T cell Western blot. Pulmonary and splenic T cells recognized 3 regions comprising <25, 55-70, and 125-140 kDa. The majority of hybridomas from lungs, but not from spleens, responded to the high molecular mass region. A protein from that area was identified, by amino acid sequencing, as a homologue of Sec31 from Saccharomyces cerevisiae. Vaccination with recombinant Sec31 reduced fungal burden and improved survival in mice, and its efficacy was critically dependent on the presence of Vβ4+ T cells. Thus, a homologue of Sec31 is a trigger of the expansion of the Vβ4+ T cell population and is important to the generation of protective immunity.
Related Links	http://dx.doi.org/10.1086/500244
Ending Page	897
Page Count	10
Starting Page	888
File Format	PDF
ISSN	00221899
e-ISSN	15376613
Journal	The Journal of infectious diseases
Issue Number	6
Volume Number	193
Language	English
Publisher Date	2006-03-15
Access Restriction	Open
Subject Keyword	Immunology and Allergy Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy

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