NDLI: Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response

Content Provider	PubMed Central
Author	Zinke, Ingo Schütz, Christina S. Katzenberger, Jörg D. Bauer, Matthias Pankratz, Michael J.
Copyright Year	2002
Abstract	We have identified genes regulated by starvation and sugar signals in Drosophila larvae using whole-genome microarrays. Based on expression profiles in the two nutrient conditions, they were organized into different categories that reflect distinct physiological pathways mediating sugar and fat metabolism, and cell growth. In the category of genes regulated in sugar-fed, but not in starved, animals, there is an upregulation of genes encoding key enzymes of the fat biosynthesis pathway and a downregulation of genes encoding lipases. The highest and earliest activated gene upon sugar ingestion is sugarbabe, a zinc finger protein that is induced in the gut and the fat body. Identification of potential targets using microarrays suggests that sugarbabe functions to repress genes involved in dietary fat breakdown and absorption. The current analysis provides a basis for studying the genetic mechanisms underlying nutrient signalling.
Related Links	http://dx.doi.org/10.1093/emboj/cdf600
Ending Page	6173
Page Count	12
Starting Page	6162
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	22
Volume Number	21
Language	English
Publisher	Oxford University Press
Publisher Date	2002-11-15
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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