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| Content Provider | PubMed Central |
|---|---|
| Author | Emerson, Suzanne U. Huang, Ying K. Nguyen, Hanh Brockington, Alicia Govindarajan, Sugantha Claire, Marisa St Shapiro, Max Purcell, Robert H. |
| Copyright Year | 2002 |
| Abstract | Fourteen different chimeric virus genomes were constructed from two infectious cDNA clones encoding a virulent and an attenuated isolate, respectively, of the HM175 strain of hepatitis A virus. The ability of each recombinant virus to infect tamarins and to cause acute hepatitis was determined. Comparisons of the genotype and phenotype of each virus suggested that VP1/2A and 2C genes were responsible for virulence. The 2C gene derived from the attenuated parent virus was unstable, and one or more mutations arose in this gene during the first passage in tamarins. |
| Related Links | http://dx.doi.org/10.1128/jvi.76.17.8551-8559.2002 |
| Ending Page | 8559 |
| Page Count | 9 |
| Starting Page | 8551 |
| File Format | |
| ISSN | 0022538X |
| e-ISSN | 10985514 |
| Journal | Journal of Virology |
| Issue Number | 17 |
| Volume Number | 76 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2002-09-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Virology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology Insect Science |
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