NDLI: Separate fusion of outer and inner mitochondrial membranes

Content Provider	PubMed Central
Author	Malka, Florence Guillery, Olwenn Carmen, Cifuentes-diaz Guillou, Emmanuelle Belenguer, Pascale Anne, Lombès Rojo, Manuel
Copyright Year	2005
Abstract	Mitochondria are enveloped by two closely apposed boundary membranes with different properties and functions. It is known that they undergo fusion and fission, but it has remained unclear whether outer and inner membranes fuse simultaneously, coordinately or separately. We set up assays for the study of inner and outer membrane fusion in living human cells. Inner membrane fusion was more sensitive than outer membrane fusion to inhibition of glycolysis. Fusion of the inner membrane, but not of the outer membrane, was abolished by dissipation of the inner membrane potential with K+ (valinomycin) or H+ ionophores (cccp). In addition, outer and inner membrane fusion proceeded separately in the absence of any drug. The separate fusion of outer and inner membranes and the different requirements of these fusion reactions point to the existence of fusion machineries that can function separately.
Related Links	http://dx.doi.org/10.1038/sj.embor.7400488
Ending Page	859
Page Count	7
Starting Page	853
File Format	PDF
ISSN	1469221X
e-ISSN	14693178
Journal	EMBO Reports
Issue Number	9
Volume Number	6
Language	English
Publisher Date	2005-09-01
Access Restriction	Open
Subject Keyword	Genetics Biochemistry Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology

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Separate fusion of outer and inner mitochondrial membranes